Anti-XK-related protein 8 XKR8 Antibody
Boster Bio Anti-XK-related protein 8 XKR8 Antibody (Catalog # A12134) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Product Specifications
Background
The XK Kell blood group complex subunit-related family member 8 (XKR8) is a member of a family of proteins that promote the phagocytosis of dying cells by altering the phospholipid distribution of the plasma membrane (1) . XKR8 is thought to be a “scramblase”, an enzyme that eliminates the asymmetry of phospholipid distribution in the plasma membrane. In apoptotic cells, XKR8 promotes the cell-surface exposure of phosphatidylserine (PtdSer) which serves as a signal for phagocytosis (1,2) .
Synonyms
XRG8, hXkr8, XRG8, XK-related protein 8
Gene Name
XKR8
UniProt
Q9H6D3
Host
Rabbit
Reactivity
Human
Cross Reactivity
XKR8 antibody is human reactive. At least two isoforms are known to exist; this antibody will detect both isoforms.
Immunogen
XKR8 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human XKR8. The immunogen is located within the last 50 amino acids of XKR8.
Clonality
Polyclonal
Applications
ELISA, WB, IHC-P, IF
Field of Research
Apoptosis
Purification
XKR8 antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
Promotes phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Has no effect on calcium-induced exposure of phosphatidylserine. Activated upon caspase cleavage, suggesting that it does not act prior the onset of apoptosis.
Molecular Weight
44655 MW
Shipping Conditions
Available
Storage Conditions
XKR8 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Fragment
IgG
Other Gene Names
XK, Kell blood group complex subunit-related family, member 8
Subcellular Location
Cell membrane
Protein Name
XK, Kell blood group complex subunit-related family, member 8
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