Anti-A-kinase anchor protein 4 AKAP4 Antibody

Boster Bio Anti-A-kinase anchor protein 4 AKAP4 Antibody (Catalog # A07362) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.

Product Specifications

Background

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell (1) . AKAP4, also known as hAKAP82, is a major sperm fibrous sheath protein that localizes to the entire length of the flagellum of human sperm (2) . It has been suggested that AKAP4 plays multiple roles in sperm motility and regulation of signal transduction pathways (2) . AKAP4 has also been postulated to be a potential biomarker for breast cancer (3) .

Synonyms

A-kinase anchor protein 4, AKAP-4, AKAP82, hAKAP82, CT99, FSC1, HI, PRKA4

Gene Name

AKAP4

UniProt

Q5JQC9

Host

Rabbit

Reactivity

Human

Cross Reactivity

AKAP4 antibody is human specific. At least three isoforms are known to exist; this antibody will detect the two longest isoforms.

Immunogen

AKAP4 antibody was raised against a 17 amino acid peptide near the amino terminus of human AKAP4. The immunogen is located within the first 50 amino acids of AKAP4.

Clonality

Polyclonal

Tissue Specificity

Testis specific; only expressed in round spermatids.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Signal Transduction

Purification

AKAP4 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Major structural component of sperm fibrous sheath. Plays a role in sperm motility.

Molecular Weight

94477 MW

Shipping Conditions

Available

Storage Conditions

AKAP4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Fragment

IgG

Other Gene Names

A kinase (PRKA) anchor protein 4

Subcellular Location

Cell projection, cilium, flagellum

Prediction Reactivity

Rat, Mouse

Protein Name

A kinase (PRKA) anchor protein 4

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