Anti-SMURF1 Antibody
Boster Bio Anti-SMURF1 Antibody (Catalog # A02823) . Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
SMURF1 (SMAD ubiquitin regulatory factor 1) is a negative regulator of TGF-beta signaling (1) . SMURF1 and SMURF2 are members of HECT domain E3 ubiquitin ligase which are involved in the enzymatic reactions of the Ub conjugating pathway (1,2) . SMURF1 negatively regulates osteoblast activity and response to bone morphogenesis protein (BMP) through controlling MEKK2 degradation (3) . SMURF1 has recently been shown to play a role in breast cancer cell migration and invasion through the downregulation of RhoA (4) .
Synonyms
SMAD specific E3 ubiquitin protein ligase 1, SMAD ubiquitination regulatory factor 1, E3 ubiquitin-protein ligase SMURF1
Gene Name
SMURF1
UniProt
Q9HCE7
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
SMURF1 antibody is human, mouse and rat reactive. At least three isoforms of SMURF1 are known to exist this antibody will recognize all three isoforms. SMURF1 is predicted to not cross-react with SMURF2.
Immunogen
SMURF1 antibody was raised against a 16 amino acid peptide near the amino terminus of human SMURF1. The immunogen is located within amino acids 180 - 230 of SMURF1.
Clonality
Polyclonal
Tissue Specificity
Expressed in melanocytes (PubMed:23999003) .
Applications
ELISA, WB, IHC-P
Field of Research
Signal Transduction, Cancer
Purification
SMURF1 antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404) . Plays a role in dendrite formation by melanocytes (PubMed:23999003) .
Molecular Weight
86114 MW
Shipping Conditions
Available
Storage Conditions
SMURF1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Fragment
IgG
Other Gene Names
SMAD specific E3 ubiquitin protein ligase 1
Subcellular Location
Cytoplasm
Protein Name
SMAD specific E3 ubiquitin protein ligase 1
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