Anti-SMURF1 Antibody

Boster Bio Anti-SMURF1 Antibody (Catalog # A02823) . Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

SMURF1 (SMAD ubiquitin regulatory factor 1) is a negative regulator of TGF-beta signaling (1) . SMURF1 and SMURF2 are members of HECT domain E3 ubiquitin ligase which are involved in the enzymatic reactions of the Ub conjugating pathway (1,2) . SMURF1 negatively regulates osteoblast activity and response to bone morphogenesis protein (BMP) through controlling MEKK2 degradation (3) . SMURF1 has recently been shown to play a role in breast cancer cell migration and invasion through the downregulation of RhoA (4) .

Synonyms

SMAD specific E3 ubiquitin protein ligase 1, SMAD ubiquitination regulatory factor 1, E3 ubiquitin-protein ligase SMURF1

Gene Name

SMURF1

UniProt

Q9HCE7

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

SMURF1 antibody is human, mouse and rat reactive. At least three isoforms of SMURF1 are known to exist this antibody will recognize all three isoforms. SMURF1 is predicted to not cross-react with SMURF2.

Immunogen

SMURF1 antibody was raised against a 16 amino acid peptide near the amino terminus of human SMURF1. The immunogen is located within amino acids 180 - 230 of SMURF1.

Clonality

Polyclonal

Tissue Specificity

Expressed in melanocytes (PubMed:23999003) .

Applications

ELISA, WB, IHC-P

Field of Research

Signal Transduction, Cancer

Purification

SMURF1 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404) . Plays a role in dendrite formation by melanocytes (PubMed:23999003) .