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Anti-NOX2 CYBB Antibody

Boster Bio Anti-NOX2 CYBB Antibody (Catalog # A00328-1) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

The NOX family of NAPDH oxidases is comprised of seven transmembrane proteins that oxidize intracellular NAPDH/NADH, causing electron transport across the membrane and the reduction of molecular oxygen to superoxide (1) . NOX2, also known as cytochrome b beta (CYBB) is one of two proteins that make up Cytochrome b-245, thought to be a primary component of the microbicidal oxidase system of phagocytes. NOX2 deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD) (2) . Activation of the NOX2 enzyme complex in microglia is thought to be neurotoxic and may play a role in Alzheimer's and Parkinson's disease (3) .

Synonyms

CGD, NOX2, AMCBX2, GP91-1, GP91PHOX, p91-PHOX, GP91-PHOX, Cytochrome b-245 heavy chain, CGD91-phox, Cytochrome b558 subunit beta

Gene Name

CYBB

UniProt

P04839

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

NOX2 antibody is human, mouse and rat reactive. At least two isoforms are known to exist; this antibody will detect both isoforms. NOX2 is predicted to not cross-react with other NOX proteins.

Immunogen

Rabbit polyclonal NOX2 antibody was raised against a 15 amino acid peptide near the amino terminus of human NOX2. The immunogen is located within amino acids 140 - 190 of NOX2.

Clonality

Polyclonal

Tissue Specificity

Detected in neutrophils (at protein level) .

Applications

ELISA, WB, IHC-P, IF

Field of Research

Immunology, Neuroscience

Purification

NOX2 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H (+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.

Molecular Weight

65336 MW

Shipping Conditions

Available

Storage Conditions

NOX2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A00328-1

Product MSDS

https://www.bosterbio.com/msds?sku=A00328-1

Fragment

IgG

Other Gene Names

Cytochrome b-245, beta polypeptide

Subcellular Location

Cell membrane; Multi-pass membrane protein. As unassembled monomer may localize to the endoplasmic reticulum.

Prediction Reactivity

Pig, Bovine

Protein Name

Cytochrome b-245, beta polypeptide

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