Anti-Corticoliberin CRH Antibody
Boster Bio Anti-Corticoliberin CRH Antibody (Catalog # A00629-2) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Product Specifications
Background
Corticotropin-releasing hormone (CRH) is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress (1) . In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta where it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturitio (2) . Marked reduction in this protein has been observed in association with Alzheimer disease (3) .
Synonyms
CRF, Corticoliberin, Corticotropin-releasing factor, CRF
Gene Name
CRH
UniProt
P06850
Host
Rabbit
Reactivity
Human
Cross Reactivity
CRH antibody is human specific.
Immunogen
CRH antibody was raised against a 16 amino acid peptide near the amino terminus of human CRH. The immunogen is located within amino acids 30 - 80 of CRH.
Clonality
Polyclonal
Tissue Specificity
Produced by the hypothalamus and placenta.
Applications
ELISA, WB, IHC-P, IF
Field of Research
Homeostasis, Neuroscience
Purification
CRH antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
Hormone regulating the release of corticotropin from pituitary gland (By similarity) . Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity) .
Molecular Weight
21422 MW
Shipping Conditions
Available
Storage Conditions
CRH antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Fragment
IgG
Other Gene Names
Corticotropin releasing hormone
Subcellular Location
Secreted
Protein Name
Corticotropin releasing hormone
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