Anti-Corticoliberin CRH Antibody

Corticotropin-releasing hormone (CRH) is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress (1) . In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta where it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturitio (2) . Marked reduction in this protein has been observed in association with Alzheimer disease (3) .

CRH antibody was raised against a 16 amino acid peptide near the amino terminus of human CRH. The immunogen is located within amino acids 30 - 80 of CRH.

Hormone regulating the release of corticotropin from pituitary gland (By similarity) . Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity) .