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Anti-DEPTOR Antibody

Boster Bio Anti-DEPTOR Antibody (Catalog # A03811) . Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

DEPTOR is an mTOR (mammalian target of rapamycin) -interacting protein whose expression is negatively regualted by mTOR complex 1 (mTORC1) and mTORC2 (1) . Loss of DEPTOR activates RP6SK1, Akt1, and SGK1, promotes cell growth and survival, and activates mTORC1 and mTORC2 kinase activities. DEPTOR expression is low in most cancers, but is often elevated in multiple myelomas (1) . In respons to stimulation by mitogens, DEPTOR is rapidly phosphorylated leading to its ubiquitination and degradation, allowing mTOR to generate an auto-amplification loop to promotes its own full activation (2) .

Synonyms

DEP.6, DEPDC6, DEP domain-containing mTOR-interacting protein, DEP domain-containing protein 6

Gene Name

DEPTOR

UniProt

Q8TB45

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

DEPTOR antibody is human, mouse and rat reactive. At least three isoforms of DEPTOR are known to exist; this antibody will detect all three isoforms.

Immunogen

DEPTOR antibody was raised against a 16 amino acid peptide near the center of human DEPTOR. The immunogen is located within amino acids 220 - 270 of DEPTOR.

Clonality

Polyclonal

Applications

ELISA, WB, IHC-P

Field of Research

Homeostasis

Purification

DEPTOR antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes.

Molecular Weight

46294 MW

Shipping Conditions

Available

Storage Conditions

DEPTOR antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Fragment

IgG

Other Gene Names

DEP domain containing MTOR-interacting protein

Protein Name

DEP domain containing MTOR-interacting protein

Frequently Asked Questions

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