Anti-Density-regulated protein DENR Antibody

Boster Bio Anti-Density-regulated protein DENR Antibody (Catalog # A06362) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

DENR (density-regulated protein), also designated DRP or smooth muscle cell associated protein 3 (SMAP-3), is a 198 amino acid protein that may be involved in the translation of target mRNAs by scanning and recognition of the initiation codon (1) . It plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1 (2,3) . DENR contains a SUI1 domain and is found in a variety of tissues with highest levels present in skeletal and cardiac muscle. It is up-regulated in ovarian and breast cancer cells by ERBB2 overexpression (4) .

Synonyms

DRP, DRP1, SMAP-3, H14, Density-regulated protein, Protein DRP1, DRP

Gene Name

DENR

UniProt

O43583

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

DENR antibody is human, mouse and rat reactive.

Immunogen

DENR antibody was raised against an 18 amino acid peptide near the center of human DENR. The immunogen is located within amino acids 80 - 130 of DENR.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in heart and skeletal muscle and moderately expressed in the brain, placenta, liver and pancreas. Weakly expressed in the lung and kidney.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Homeostasis

Purification

DENR antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.