Anti-LAMTOR3 Antibody

The late endosomal/lysosomal adaptor MAPK and MTOR activator 3 (LAMTOR3) protein belongs to the LAMTOR family of proteins, and together with LAMTOR2 and the MAPK1 and ERK kinase 1 (MEK1) localizes to late endosomes where it is required for the efficient activation of ERK signaling (1,2) . This complex is involved in the regulation of late endosomal traffic and cellular proliferation (3) and plays a role in cellular host defense against Salmonella infection (4) .

LAMTOR3 antibody is human, mouse and rat reactive. At least two isoforms of LAMTOR3 are known to exist; this antibody will detect both isoforms. LAMTOR3 antibody is predicted to not cross-react with other LAMTOR family proteins.

LAMTOR3 antibody was raised against an 15 amino acid peptide near the center of human LAMTOR3. The immunogen is located within amino acids 40 - 90 of LAMTOR3.

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.