Anti-GLIPR1-like protein 1 GLIPR1L1 Antibody

The GLIPR1-like 1 protein (GLIPR1L1) gene is part of a p53 target gene cluster that includes the related proteins GLIPR1 and GLIPR1L2 (1) . GLIPR1L1 is similar to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family (2) . GLIPR1 is a tumor suppressor whose expression is regulated by p53 (3) . Unlike GLIPR1, GLIPR1L1 is expressed primarily in the testis and is thought to be involved in the binding of sperm to the oocyte complex (4) .

GLIPR1L1 antibody is human specific. At least two isoforms of GLIPR1L1 are known to exist; this antibody will detect both isoforms. This antibody is predicted to not cross-react with other GLIPR or GLIPR-like proteins.

GLIPR1L1 antibody was raised against an 18 amino acid peptide near the amino terminus of human GLIPR1L1 . The immunogen is located within amino acids 20 - 70 of GLIPR1L1.

Plays a role in the binding between sperm and oocytes. Component of epididymosomes, one type of membranous microvesicules which mediate the transfer of lipids and proteins to spermatozoa plasma membrane during epididymal maturation. Also component of the CD9-positive microvesicules found in the cauda region.