Anti-TMIGD2 Antibody

TMIGD2 (transmembrane and immunoglobulin domain containing 1), also known as immunoglobulin-containing and proline-rich receptor 1 (IGPR1), is novel adhesion molecule that is expressed in multiple tissues, primarily in cells of epithelium and endothelium origins (1) . TMIGD2 is thought to be involved in angiogenesis and regulates cellular morphology, homophilic cell aggregation, and cell-cell interaction. TMIGD2 activity also modulates actin stress fiber formation and focal adhesion and reduces cell migration (1) .

TMIGD2 antibody is human and mouse reactive. At least three isoforms of TMIGD2 are known to exist; this antibody will detect all three. TMIGD2 antibody is predicted to not cross-react with TMIGD1.

TMIGD2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human TMIGD2. The immunogen is located within the last 50 amino acids of TMIGD2.

Widely expressed, mainly by epithelial and endothelial cells, including bronchial epithelial cells of lung, breast glandular and lobular epithelia cells, urothelium of the bladder, skin epidermis, epithelium of gastrointestinal, rectum, endometrial glands of the uterus, ureter, fallopian tube epithelium, colonic epithelium, small bowl epithelium, stomach epithelium, including both chief and parietal cells, trophoblastic epithelium of placenta, and pancreatic acinar cells (at protein level) . Consistently expressed in veins and arteries (at protein level) . Not detected in thyroid, cerebellum, cerebral cortex and thymus (at protein level) . Expressed in lymphoid organs, with highest levels in thymus, spleen, peripheral blood lymphocytes and liver. In the thymus, expressed in CD4+ and CD8+ single- and double-positive cells, but not in immature CD4- and CD8- double- negative cells (at protein level) . In peripheral blood mononuclear cells, highly expressed on CD56+ or CD16+ natural killer cells and CD3+ T-cells (at protein level) . Not detected on B-cells (at protein level) . Expressed in tonsils (at protein level) .

Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T- cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.