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Anti-Polyhomeotic-like protein 3 PHC3 Antibody

Boster Bio Anti-Polyhomeotic-like protein 3 PHC3 Antibody (Catalog # A08917) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Polycomb group (PcG) proteins assemble into multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes throughout development (1) . PHC3 (Polyhomeotic-like protein 3), also known as Early development regulatory protein 3, is a 983 amino acid nuclear protein that is a component of the PcG multiprotein PRC1 complex (2) . PRC1 complex acts via chromatin remodeling and modification of histones. PHC3 contains 1 FCS-type zinc finger and SAM (sterile alpha motif) domain (2-3) . PHC 3 has been regarded as a candidate tumor suppressor of osteosarcoma (4) .

Synonyms

EDR3, HPH3, EDR3, PH3, Polyhomeotic-like protein 3, Early development regulatory protein 3, hPH3

Gene Name

PHC3

UniProt

Q8NDX5

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

PHC3 antibody is human, mouse and rat specific. At least six isoforms of PHC3 are known to exist.

Immunogen

PHC3 antibody was raised against a 19 amino acid peptide near the amino terminus of human PHC3. The immunogen is located within amino acids 240 - 290 of PHC3.

Clonality

Polyclonal

Applications

ELISA, WB

Field of Research

Stem Cells

Purification

PHC3 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Molecular Weight

106162 MW

Shipping Conditions

Available

Storage Conditions

PHC3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A08917

Product MSDS

https://www.bosterbio.com/msds?sku=A08917

Fragment

IgG

Other Gene Names

Polyhomeotic homolog 3 (Drosophila)

Subcellular Location

Nucleus

Protein Name

Polyhomeotic homolog 3 (Drosophila)

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