Anti-Protein TESPA1 TESPA1 Antibody

TESPA1 is a critical component of the TCR signalosome and is essential for T cell selection and maturation through the regulation of TCR signaling during T cell development (1) . TESPA1 encodes a protein of 458 amino acids and is highly conserved among vertebrate species (2) . TESPA1 expression was tightly regulated during T cell development, with highest expression at the DP stage (3) . TESPA1 deficiency resulted in failure of positive selection and substantially fewer of CD4+ and CD8+ SP cells in the thymus (1,4) .

TESPA1 antibody was raised against an 18 amino acid peptide near the amino terminus of human TESPA1. The immunogen is located within amino acids 20 - 70 of TESPA1.

Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity) . Plays a role in T-cell antigen receptor (TCR) -mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca (2+) release and mitochondrial Ca (2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment.