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Anti-Protein TESPA1 TESPA1 Antibody

Boster Bio Anti-Protein TESPA1 TESPA1 Antibody (Catalog # A09477) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human.

Product Specifications

Background

TESPA1 is a critical component of the TCR signalosome and is essential for T cell selection and maturation through the regulation of TCR signaling during T cell development (1) . TESPA1 encodes a protein of 458 amino acids and is highly conserved among vertebrate species (2) . TESPA1 expression was tightly regulated during T cell development, with highest expression at the DP stage (3) . TESPA1 deficiency resulted in failure of positive selection and substantially fewer of CD4+ and CD8+ SP cells in the thymus (1,4) .

Synonyms

HSPC257, KIAA0748, HSPC257, Protein TESPA1, Thymocyte-expressed positive selection-associated protein 1

Gene Name

TESPA1

UniProt

A2RU30

Host

Rabbit

Reactivity

Human

Cross Reactivity

TESPA1 antibody is human specific. At least three isoforms TESPA1 are known to exist.

Immunogen

TESPA1 antibody was raised against an 18 amino acid peptide near the amino terminus of human TESPA1. The immunogen is located within amino acids 20 - 70 of TESPA1.

Clonality

Polyclonal

Applications

ELISA, WB, ICC, IF

Field of Research

Immunology

Purification

TESPA1 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity) . Plays a role in T-cell antigen receptor (TCR) -mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca (2+) release and mitochondrial Ca (2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment.

Molecular Weight

59213 MW

Shipping Conditions

Available

Storage Conditions

TESPA1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A09477

Product MSDS

https://www.bosterbio.com/msds?sku=A09477

Fragment

IgG

Other Gene Names

Thymocyte expressed, positive selection associated 1

Subcellular Location

Cytoplasm

Prediction Reactivity

Mouse

Protein Name

Thymocyte expressed, positive selection associated 1

Curated Selection

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