Anti-COMMD7 Antibody

Boster Bio Anti-COMMD7 Antibody (Catalog # A09709) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

COMMD7 (COMM domain-containing protein 7) plays a role in the regulation NF-kappaB (1) . It associates with the NF-kB complex and suppresses its transcriptional activity (2) . COMMD7 contains 1 COMM domain and widely expressed with highest expression in lung (3) . COMMD7 is a newly identified gene overexpressed in hepatocellular carcinoma (HCC) (4) . COMMD7 is associated with tumor invasion and poor prognosis by NF-kappaB signaling pathway (4) .

Synonyms

C20orf92, dJ1085F17.3, C20orf92, COMM domain-containing protein 7

Gene Name

COMMD7

UniProt

Q86VX2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

COMMD7 antibody is human, mouse and rat reactive. Multiple transcript variants encoding different isoforms have been found for COMMD7.

Immunogen

COMMD7 antibody was raised against a 19 amino acid peptide near the center of human COMMD7. The immunogen is located within amino acids 90 - 140 of COMMD7.

Clonality

Polyclonal

Applications

ELISA, WB, IHC-P, IF

Field of Research

Cancer, Cell Cycle

Purification

COMMD7 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237) . Associates with the NF-kappa-B complex and suppresses its transcriptional activity (PubMed:15799966) .