Anti-LRRC26 Antibody

Boster Bio Anti-LRRC26 Antibody (Catalog # A09062) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.

Product Specifications

Background

The LRRC26 protein was initially identified as a cytokeratin-associated protein whose expression was elevated in multiple cancer cell lines and cancer specimens as well in normal prostate and salivary gland tissues (1) . LRRC26 was later found to negatively regulate the NF-kappaB activation and suppresses tumor growth and metastasis (2) . LRRC26 can also act to selectively alter the efficacy of large conductance calcium-activated K (BK) channels (3) .

Synonyms

CAPC, bA350O14.10, CAPC, Leucine-rich repeat-containing protein 26, BK channel auxiliary gamma subunit LRRC26

Gene Name

LRRC26

UniProt

Q2I0M4

Host

Rabbit

Reactivity

Human

Cross Reactivity

LRRC26 antibody is human specific.

Immunogen

LRRC26 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human LRRC26. The immunogen is located within the last 50 amino acids of LRRC26.

Clonality

Polyclonal

Tissue Specificity

Isoform 1 is expressed highly in normal prostate and salivary gland, very weakly in colon, pancreas, and intestine, and not at all in other tissues. Isoform 1 is expressed highly in many cancer cell lines and in breast cancer, pancreatic cancer and colon cancer. Isoform 2 is expressed in cancer cell lines.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Cancer, Cell Cycle

Purification

LRRC26 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha) . Required for the conversion of BK alpha channels from a high-voltage to a low- voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium.