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Anti-KDM1B Antibody

Boster Bio Anti-KDM1B Antibody (Catalog # A08071) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

Flavin-dependent histone demethylases regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (reviewed in 1) . KDM1B is a recently identified histone H3K4 demethylase that is required to establish maternal genomic imprints; targeted disruption of the KDM1B gene in mice led to lethality in their embryos, suggesting demethylation of H3K4 is critical for establishing the DNA methylation imprints (2) . KDM1B has also been shown to play a role in the transcription elongation in several genes (3) .

Synonyms

AOF1, LSD2, C6orf193, bA204B7.3, dJ298J15.2, AOF1, Lysine-specific histone demethylase 1B, Flavin-containing amine oxidase domain-containing protein 1

Gene Name

KDM1B

UniProt

Q8NB78

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

KDM1B antibody is human, mouse and rat reactive. At least two isoforms of KDM1B are known to exist; this KDM1B antibody will detect both isoforms.

Immunogen

KDM1B antibody was raised against a 17 amino acid peptide near the amino terminus of human KDM1B. The immunogen is located within amino acids 80 - 130 of KDM1B.

Clonality

Polyclonal

Applications

ELISA, WB

Field of Research

Homeostasis

Purification

KDM1B antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri- methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys- 36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4.

Molecular Weight

92098 MW

Shipping Conditions

Available

Storage Conditions

KDM1B antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A08071

Product MSDS

https://www.bosterbio.com/msds?sku=A08071

Fragment

IgG

Other Gene Names

Lysine (K) -specific demethylase 1B

Subcellular Location

Nucleus .

Protein Name

Lysine (K) -specific demethylase 1B

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