Anti-AIMP1 Antibody

AIMP1 (Endothelial monocyte-activating polypeptide II, EMAP2) is a proinflammatory cytokine for monocytes and granulocytes (1) . It is specifically induced by apoptosis and is involved in the control of angiogenesis, inflammation, and wound healing (1,2) . AIMP1 was identified as one of three auxiliary factors of the mammalian aminoacyl tRNA synthetase (ARS) complex. It binds and facilitates the catalytic reaction of arginyl-tRNA synthetase (2,3) . Recent studies show that CD23 plays an essential role in the AIMP1-induced immune response and might be a target in the treatment of inflammatory diseases (4) .

P43, HLD3, EMAP2, SCYE1, EMAPII, Aminoacyl tRNA synthase complex-interacting multifunctional protein 1, Multisynthase complex auxiliary component p43, EMAP-2

AIMP1 antibody is human, mouse and rat reactive. At least two isoforms of AIMP1 are known to exist; this antibody will recognize both isoforms. AIMP1 antibody is predicted to not cross-react with AIMP2.

AIMP1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human AIMP1. The immunogen is located within amino acids 240 - 290 of AIMP1.

Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (PubMed:10358004) . Binds tRNA. Possesses inflammatory cytokine activity (PubMed:11306575) . Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation (By similarity) . Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity) . Promotes dermal fibroblast proliferation and wound repair (PubMed:16472771) . Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity) . Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (PubMed:12237313) . Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:11818442) . Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (PubMed:19362550) .