Anti-IL-36RN Antibody

IL-36RN is is a member of the interleukin 1 cytokine family whose gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2 (1) . IL-36RN specifically inhibits the activation of NF-kappaB induced IL-36A (2) . The opposing activities of these cytokines have been suggested to be involved in the regulation of skin inflammation (3) . Like the IL-36 cytokines (IL-36A, IL-36B and IL-36G), IL-36RN requires post-translational processing for full agonist activity, but the cleavage mechanism is currently unknown (4) .

FIL1, FIL1D, IL1F5, IL1L1, PSORP, IL1HY1, IL1RP3, IL36RA, FIL1 (DELTA), UNQ1896/PRO4342, Interleukin-36 receptor antagonist protein, FIL1 delta, IL-1RP3

IL-36RN antibody was raised against a 19 amino acid peptide near the carboxy terminus of human IL-36RN. The immunogen is located within the last 50 amino acids of IL-36RN.

Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.

Inhibits the activity of interleukin-36 (IL36A, IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.