Anti-IL-9 Antibody

Interleukin 9 (IL-9) is a cytokine secreted by TH2 lymphocytes that acts as a regulator of a variety of hematopoietic cells, stimulates cell proliferation and prevents apoptosis (1,2) . It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins (3) . The IL-9 gene has been identified as a candidate gene for asthma (4) . Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness (5) .

Anti-IL-9 antibody was raised against a peptide corresponding to 16 amino acids near the carboxy terminus of human IL-9. The immunogen is located within the last 50 amino acids of IL-9.