Anti-Transmembrane protein 107 TMEM107 Antibody

Transmembrane protein 107 (TMEM 107) is critical for cilia formation and embryonic patterning (1) . It is a 139 amino acid transmembrane protein encoded by a gene that maps to human chromosome 17 which is associated with two key tumor suppressor genes p53 and BRCA1 (1,2) . TMEM107 is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types (1,3) . TMEM107 is also a strong candidate gene for central areolar choroidal dystrophy (CACD) (1-3) .

TMEM107 antibody was raised against a 19 amino acid peptide near the amino terminus of human TMEM107. The immunogen is located within amino acids 20 - 70 of TMEM107 .

Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity) . During ciliogenesis regulates the ciliary transition zone localization of some MKS complex proteins (PubMed:26518474) .