Anti-TFPI Antibody

Boster Bio Anti-TFPI Antibody (Catalog # A01052-1) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Tissue factor pathway inhibitor (TFPI), also known as lipoprotein-associated coagulation inhibitor, is a protease inhibitor that regulates the tissue factor (TF) -dependent pathway of blood coagulation (1) . TFPI is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. TFPI inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop (1) .

Synonyms

EPI, TFI, LACI, TFPI1, Tissue factor pathway inhibitor, Extrinsic pathway inhibitor, TFPI

Gene Name

TFPI

UniProt

P10646

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

TFPI antibody is human, mouse and rat reactive. At least two isoforms of TFPI are known to exist; this antibody will detect both isoforms.

Immunogen

TFPI antibody was raised against a 13 amino acid peptide near the amino terminus of human TFPI. The immunogen is located within amino acids 70 - 120 of TFPI.

Clonality

Polyclonal

Tissue Specificity

Mostly in endothelial cells.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Signal Transduction

Purification

TFPI Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Inhibits factor X (X (a) ) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.