Anti-KHDC1 Antibody

KHDC1 family members are K-homology (KH) domain-containing RNA binding proteins that are involved in various aspects of RNA metabolism, ranging from transcription to RNA splicing, transportation, translation, and stability (1) . KHDC1 is highly expressed in oocytes and interacts with cytoplasmic polyadenylation element-binding protein 1 (CPEB1), a key translational regulator controlling the polyA length of mRNAs (2,3) . KHDC1 functions as a global translational repressor and induces apoptosis through an ER-dependent signaling pathway and that the C-terminal putative trans-membrane motif (TMM) is critical for its activities (3,4) .

KHDC1 antibody is human, mouse and rat reactive. At least three isoforms of KHDC1 are known to exist; this antibody will only detect the longest isoform.

KHDC1 antibody was raised against a 15 amino acid peptide near the amino terminus of human KHDC1. The immunogen is located within amino acids 30 - 80 of KHDC1.