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Anti-TLX1 Antibody

Boster Bio Anti-TLX1 Antibody (Catalog # A04342) . Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX1, also called homeobox11 (HOX11), as it is located outside of the four mammalian Hox clusters, is a DNA-binding nuclear transcription factor. TLX1 encodes a homeobox-domain containing protein and is containing a glycine and proline-rich amino terminus. TLX1 is required for maintenance of the developing spleen and cell survival. TLX1 is highly expressed in T-cell leukemia and lymphoid neoplasias as a result of translocation. TLX1-deficient mice have no spleen.

Synonyms

TCL3, HOX11, TCL3, T-cell leukemia homeobox protein 1, Homeobox protein Hox-11

Gene Name

TLX1

UniProt

P31314

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

Multiple isoforms of TLX1 exist due to alternative splicing events. TLX1 antibody is predicted to not cross-react with other TLX proteins.

Immunogen

TLX1 antibody was raised against a 16 amino acid peptide near the amino terminus of human TLX1. The immunogen is located within the first 50 amino acids of TLX1.

Clonality

Polyclonal

Applications

ELISA, WB, IHC-P

Field of Research

Stem Cells

Purification

TLX1 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.

Molecular Weight

34365 MW

Shipping Conditions

Available

Storage Conditions

TLX1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A04342

Product MSDS

https://www.bosterbio.com/msds?sku=A04342

Fragment

IgG

Other Gene Names

T-cell leukemia homeobox 1

Subcellular Location

Nucleus .

Protein Name

T-cell leukemia homeobox 1

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