Anti-Guanylate-binding protein 5 GBP5 Antibody

Boster Bio Anti-Guanylate-binding protein 5 GBP5 Antibody (Catalog # A07110) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

The guanylate-binding proteins (GBPs) are a family of interferon-induced GTP-binding proteins function in innate immunity against microbial and viral pathogens. In humans, there are seven GBPs from hGBP1 to hGBP7. Human GBP1 and GBP2 have been shown to exhibit antiviral activity as well as being able to regulate the inhibition of proliferation and invasion of endothelial cells in response to interferon (IFN) . GBP5 promotes selective NALP3 inflammasome responses to pathogenic bacteria and soluble but not crystalline inflammasome priming agents.

Synonyms

GBP-5, Guanylate-binding protein 5, GBP-TA antigen, GBP-5

Gene Name

GBP5

UniProt

Q96PP8

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

GBP5 antibody is predicted to not cross-react with other GBP family members.

Immunogen

GBP5 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human GBP5 . The immunogen is located within the last 50 amino acids of GBP5.

Clonality

Polyclonal

Tissue Specificity

Expressed in peripheral blood monocytes (at protein level) .

Applications

ELISA, WB, IHC-P, IF

Field of Research

Innate Immunity

Purification

GBP5 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501) . Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847) .