Anti-TIAF TIAF1 Antibody

Boster Bio Anti-TIAF TIAF1 Antibody (Catalog # A12896) . Tested in ELISA, WB, ICC applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

TIAF-1 (TGFB1-induced anti-apoptotic factor 1), also known as MYO18A, is a TGFB1-induced anti-apoptotic factor that functions to inhibit the cytotoxic effects of TNF-alpha, TRADD and FADD. It localizes to the nucleus and significantly up-regulated in activated helper T lymphocytes (TH2) in chronic kidney and liver allograft rejection. Suppression of TIAF1 expression by siRNA prevents UV irradiation-mediated p53 phosphorylation and nuclear translocation. TIAF1 is essential in the p53- and WOX1-mediated cell death and shows an aggregation-dependent control of tumor progression and metastasis, and regulation of cell death.

Synonyms

MAJN, SPR210, TGFB1-induced anti-apoptotic factor 1, 12 kDa TGF-beta-1-induced antiapoptotic factor

Gene Name

TIAF

UniProt

O95411

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

Two alternatively spliced transcript variants encoding different isoforms have been identified.

Immunogen

TIAF antibody was raised against a 16 amino acid peptide near the amino terminus of human TIAF . The immunogen is located within the first 50 amino acids of TIAF.

Clonality

Polyclonal

Tissue Specificity

Not detectable in normal kidney and liver. Up- regulated in chronic and acute allograft rejection: expressed in the inflammatory infiltrate and in tubular epithelial cells.

Applications

ELISA, WB, ICC

Field of Research

Apoptosis

Purification

TIAF Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation.