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Anti-TYK2 Antibody

Boster Bio Anti-TYK2 Antibody (Catalog # A01642-1) . Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

TYK2 is a member of the Janus kinases (JAKs) protein families. TYK2 associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits and is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

Synonyms

JTK1, Non-receptor tyrosine-protein kinase TYK2

Gene Name

TYK2

UniProt

P29597

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

At least three isoforms of TYK2 are known to exist; this antibody only detects the two longest isoforms.

Immunogen

Rabbit polyclonal TYK2 antibody was raised against a 17 amino acid peptide near the amino terminus of human TYK2. The immunogen is located within amino acids 90 - 140 of TYK2.

Clonality

Polyclonal

Tissue Specificity

Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.

Applications

ELISA, WB, IF

Field of Research

Signal Transduction

Purification

TYK2 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.

Molecular Weight

133650 MW

Shipping Conditions

Available

Storage Conditions

TYK2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A01642-1

Product MSDS

https://www.bosterbio.com/msds?sku=A01642-1

Fragment

IgG

Other Gene Names

Tyrosine kinase 2

Protein Name

Tyrosine kinase 2

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