Anti-TYK2 Antibody
Boster Bio Anti-TYK2 Antibody (Catalog # A01642-1) . Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
TYK2 is a member of the Janus kinases (JAKs) protein families. TYK2 associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits and is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
Synonyms
JTK1, Non-receptor tyrosine-protein kinase TYK2
Gene Name
TYK2
UniProt
P29597
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
At least three isoforms of TYK2 are known to exist; this antibody only detects the two longest isoforms.
Immunogen
Rabbit polyclonal TYK2 antibody was raised against a 17 amino acid peptide near the amino terminus of human TYK2. The immunogen is located within amino acids 90 - 140 of TYK2.
Clonality
Polyclonal
Tissue Specificity
Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
Applications
ELISA, WB, IF
Field of Research
Signal Transduction
Purification
TYK2 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
Molecular Weight
133650 MW
Shipping Conditions
Available
Storage Conditions
TYK2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Fragment
IgG
Other Gene Names
Tyrosine kinase 2
Protein Name
Tyrosine kinase 2
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