Anti-Zinc finger protein PLAGL2 PLAGL2 Antibody

The PLAG (Pleiomorphic adenoma gene) family of zinc finger proteins include PLAG1, ZAC1 and PLAG-like 2 (PLAGL2) . PLAG1 is the target gene for the pleiomorphic adenomas of the salivary gland. ZAC1 (PLAGL1) concomitantly controls apoptosis and cell cycle arrest through separate pathways. ZAC1 also acts as a transcriptional cofactor for nuclear receptors. PLAGL2 belongs to the krueppel C2H2-type zinc-finger protein family and contains 6 C2H2-type zinc fingers. It functions as a positive regulator of transcription and localizes to the nucleus. PLAGL2 is ubiquitously expressed with particular abundance in spleen, lung and testis, where it may be involved in cell cycle arrest and apoptosis of tumor cells.

PLAGL2 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human PLAGL2. The immunogen is located within amino acids 40 - 90 of PLAGL2.

PLAGL2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.