Anti-SGSM2 Antibody

Boster Bio Anti-SGSM2 Antibody (Catalog # A12146) . Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Small G proteins such as RAP and RAB proteins are the key molecules in intracellular signal transduction and vesicle transportation. A novel protein family small G protein signaling modulator (SGSM) consisting of three members SGSM1-3 bind to RAP and RAB family proteins. All three SGSM proteins possess both a RUN domain and a TBC domain. SGSM2 is a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins.

Synonyms

RUTBC1, KIAA0397, RUTBC1, Small G protein signaling modulator 2, RUN and TBC1 domain-containing protein 1

Gene Name

SGSM2

UniProt

O43147

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

Multiple isoforms of SGSM2 are known to exist. SGSM2 antibody is predicted to not cross react with other SGSM family proteins.

Immunogen

SGSM2 antibody was raised against an 18 amino acid synthetic peptide near the center of human SGSM2. The immunogen is located within amino acids 650 - 700 of SGSM2.

Clonality

Polyclonal

Tissue Specificity

Widely expressed.

Applications

ELISA, WB, IF

Field of Research

Neuroscience

Purification

SGSM2 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Possesses GTPase activator activity towards RAB32, RAB33B and RAB38 (PubMed:26620560, PubMed:21808068) . Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation (PubMed:26620560) .

Molecular Weight

113285 MW

Shipping Conditions

Available

Storage Conditions

SGSM2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.