Anti-SGSM2 Antibody
Boster Bio Anti-SGSM2 Antibody (Catalog # A12146) . Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
Small G proteins such as RAP and RAB proteins are the key molecules in intracellular signal transduction and vesicle transportation. A novel protein family small G protein signaling modulator (SGSM) consisting of three members SGSM1-3 bind to RAP and RAB family proteins. All three SGSM proteins possess both a RUN domain and a TBC domain. SGSM2 is a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins.
Synonyms
RUTBC1, KIAA0397, RUTBC1, Small G protein signaling modulator 2, RUN and TBC1 domain-containing protein 1
Gene Name
SGSM2
UniProt
O43147
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
Multiple isoforms of SGSM2 are known to exist. SGSM2 antibody is predicted to not cross react with other SGSM family proteins.
Immunogen
SGSM2 antibody was raised against an 18 amino acid synthetic peptide near the center of human SGSM2. The immunogen is located within amino acids 650 - 700 of SGSM2.
Clonality
Polyclonal
Tissue Specificity
Widely expressed.
Applications
ELISA, WB, IF
Field of Research
Neuroscience
Purification
SGSM2 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
Possesses GTPase activator activity towards RAB32, RAB33B and RAB38 (PubMed:26620560, PubMed:21808068) . Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation (PubMed:26620560) .
Molecular Weight
113285 MW
Shipping Conditions
Available
Storage Conditions
SGSM2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Other Gene Names
Small G protein signaling modulator 2
Subcellular Location
Cytoplasm
Protein Name
Small G protein signaling modulator 2
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