Anti-SELK SELENOK Antibody

SELK is a selenoprotein, containing a selenocysteine residue at its active site. SELK is localized to the endoplasmic reticulum and is highly expressed in the heart, where it may function as an antioxidant. SELK can bind to proteins such as the ER-associated degradation (ERAD) components p97 ATPase, Derlin-1 and -2, and SelS as well as proteins in the oligosaccharyltransferase complex, suggesting that SELK may be involved in the Derlin-dependent ERAD of glycosylated misfolded proteins. SELK is also thought to be important in Ca2+ flux in immune cells, and is cleaved by m-calpain in resting macrophages. When these macrophages are activated through different Toll-like receptors, this cleavage is inhibited

SELK antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human SELK. The immunogen is located within the last 50 amino acids of SELK.

Required for Ca (2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity) . Involved in endoplasmic reticulum- associated degradation (ERAD) of soluble glycosylated proteins (PubMed:22016385) . Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low- density lipoprotein and in foam cell formation (By similarity) . Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151) . Plays a role in protection of cells from ER stress-induced apoptosis (PubMed:20692228) . Protects cells from oxidative stress when overexpressed in cardiomyocytes (PubMed:16962588) .

SELK antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.