Anti-TCIRG1 Antibody

Boster Bio Anti-TCIRG1 Antibody (Catalog # A05045) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

The T-cell immune regulator 1 (TCIRG1) is the a3 subunit of the vacuolar-type proton transporting ATPase (V-ATPase), a proton pump in late endosomes and lysosomes that functions in the luminal acidification of these organelles. Genetic defects in the gene encoding this protein a responsible for a severe form of autosomal recessive osteopetrosis, a condition that leads to increased bone density, decreased bone strength, and inflammation in bone tissues. TCIRG1 is also required for the normal secretion of insulin and the bacteria-killing function of macrophages.

Synonyms

A3, Stv1, Vph1, Atp6i, OC116, OPTB1, TIRC7, ATP6N1C, ATP6V0A3, OC-116kDa, V-type proton ATPase 116 kDa subunit a isoform 3, Osteoclastic proton pump 116 kDa subunit, V-ATPase 116 kDa isoform a3

Gene Name

TCIRG1

UniProt

Q13488

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

At least two alternatively spliced isoforms are known to exist; this antibody will only detect the larger isoform.

Immunogen

TCIRG1 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human TCIRG1. The immunogen is located within amino acids 70 - 120 of TCIRG1.

Clonality

Polyclonal

Tissue Specificity

Isoform long is highly expressed in osteoclastomas. Isoform short is highly expressed in thymus.

Applications

ELISA, WB

Field of Research

Immunology

Purification

TCIRG1 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Part of the proton channel of V-ATPases (By similarity) . Seems to be directly involved in T-cell activation. .

Molecular Weight

92968 MW

Shipping Conditions

Available

Storage Conditions

TCIRG1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.