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Anti-CLEC2A Antibody

Boster Bio Anti-CLEC2A Antibody (Catalog # A11588) . Tested in ELISA, WB, IF applications. This antibody reacts with Human.

Product Specifications

Background

CLEC2A (C-type lectin domain family 2 member A), also known as PILAR (proliferation-induced lymphocyte-associated receptor) is involved in modulating T-cell expansion. It is a 32 kDa single-pass type II membrane protein that contains one C-type lectin domain in its extracellular region and belongs to the CTL/CTLD superfamily. CLEC2A is mainly expressed in skin and highly expressed in CD8 (+), B lymphocytes and naive CD4 (+) T cells. Manipulation of CLEC2A signaling may be important for treatment of autoimmune diseases and cancer.

Synonyms

KACL, PILAR, UNQ5792, KACL, UNQ5792/PRO19597, C-type lectin domain family 2 member A, Keratinocyte-associated C-type lectin

Gene Name

CLEC2A

UniProt

Q6UVW9

Host

Rabbit

Reactivity

Human

Cross Reactivity

CLEC2A antibody is human specific. Two alternatively spliced transcript variants have been observed.

Immunogen

CLEC2A antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CLEC2A. The immunogen is located within the first 50 amino acids of CLEC2A.

Clonality

Polyclonal

Tissue Specificity

Mainly expressed in skin. Also expressed in keratinocytes, spleen, thymus, small intestine, peripheral blood monocytes, bone marrow, ovary, testis and skin. High expression in CD8 (+), B-lymphocytes and naive CD4 (+) T-cells. Restricted mostly to proliferating lymphocytes. Not detected in myeloid leukocytes or natural killer (NK) cells.

Applications

ELISA, WB, IF

Field of Research

Immunology

Purification

CLEC2A Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti- apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity.

Molecular Weight

19972 MW

Shipping Conditions

Available

Storage Conditions

CLEC2A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A11588

Product MSDS

https://www.bosterbio.com/msds?sku=A11588

Fragment

IgG

Other Gene Names

C-type lectin domain family 2, member A

Subcellular Location

Cell membrane

Protein Name

C-type lectin domain family 2, member A

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