Anti-DDX60 Antibody
Boster Bio Anti-DDX60 Antibody (Catalog # A09938) . Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
DDX60 is a DEXD/H Box RNA helicase and the human homolog of the S. cerevisiae Ski2, a cofactor of RNA exosome. Expression of DDX60 increases after viral infection and binds to endogenous RIG-I, a cytoplasmic viral RNA sensor, as well as other RIG-I-like receptors such as MDA5 and LGP2. These proteins activate TBK1 and IKK-e, signaling IRF3 and NF-kB-responsive genes in the innate immune response pathway. DDX60 is required for the RIG-I- or MDA5-dependent response to viral infection, but is dispensable for TLR3-mediated signaling.
Synonyms
Probable ATP-dependent RNA helicase DDX60, DEAD box protein 60
Gene Name
DDX60
UniProt
Q8IY21
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
At least three isoforms of DDX60 are known to exist; this antibody will detect all three isoforms.
Immunogen
DDX60 antibody was raised against a 17 amino acid synthetic peptide near the center of human DDX60. The immunogen is located within amino acids 1140 - 1190 of DDX60.
Clonality
Polyclonal
Tissue Specificity
Brain, lymph node, prostate, stomach, thyroid, tongue, trachea, uterus, skeletal muscle, spleen, kidney, liver and small intestine.
Applications
ELISA, WB, IF
Field of Research
Innate Immunity
Purification
DDX60 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
Positively regulates DDX58/RIG-I- and IFIH1/MDA5- dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV) .
Molecular Weight
197853 MW
Shipping Conditions
Available
Storage Conditions
DDX60 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Other Gene Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
Subcellular Location
Cytoplasm
Protein Name
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
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