Anti-COH1 VPS13B Antibody

Boster Bio Anti-COH1 VPS13B Antibody (Catalog # A04566) . Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

COH1 (Cohen syndrome protein 1), also known as VPS13B (vacuolar protein sorting-associated protein 13B) or CHS1, belongs to the VPS13 family and may function in vesicle-mediated transport and sorting of proteins within the cell. COH1 is widely expressed and multiple alternatively spliced transcript variants have been observed. Mutations in this gene have been associated with Cohen syndrome. COH1 is a Golgi-localized peripheral membrane protein and plays a critical role in Golgi (re) assembly.

Synonyms

CHS1, COH1, CHS1, KIAA0532, Vacuolar protein sorting-associated protein 13B, Cohen syndrome protein 1

Gene Name

VPS13B

UniProt

Q7Z7G8

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

At least five alternatively spliced transcript variants have been observed. COH1 detects two isoforms.

Immunogen

COH1 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human COH1. The immunogen is located within amino acids 90 - 140 of COH1.

Clonality

Polyclonal

Tissue Specificity

Widely expressed. There is apparent differential expression of different transcripts. In fetal brain, lung, liver, and kidney, two transcripts of 2 and 5 kb are identified. These transcripts are also seen in all adult tissues analyzed. A larger transcript (12-14 kb) is expressed in prostate, testis, ovary, and colon in the adult. Expression is very low in adult brain tissue. Isoform 1 and isoform 2 are expressed in brain and retina. Isoform 2 is expressed ubiquitously.

Applications

ELISA, WB, IF

Field of Research

Homeostasis

Purification

COH1 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

May be involved in protein sorting in post Golgi membrane traffic. .

Molecular Weight

448664 MW

Shipping Conditions

Available

Storage Conditions

COH1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.