Anti-DELE DELE1 Antibody

DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-α and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-α , anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.

DELE antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human DELE. The immunogen is located within the first 50 amino acids of DELE.

DELE antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.