Anti-DELE DELE1 Antibody

Boster Bio Anti-DELE DELE1 Antibody (Catalog # A31772) . Tested in ELISA, WB, IF applications. This antibody reacts with Human, Rat.

Product Specifications

Background

DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-α and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-α , anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.

Synonyms

DELE, DELE, Death ligand signal enhancer

Gene Name

KIAA0141

UniProt

Q14154

Host

Rabbit

Reactivity

Human, Rat

Immunogen

DELE antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human DELE. The immunogen is located within the first 50 amino acids of DELE.

Clonality

Polyclonal

Tissue Specificity

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Applications

ELISA, WB, IF

Field of Research

Apoptosis

Purification

DELE Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.

Molecular Weight

55920 MW

Shipping Conditions

Available

Storage Conditions

DELE antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.