Anti-SARM SARM1 Antibody

Boster Bio Anti-SARM SARM1 Antibody (Catalog # A03633-1) . Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SARM (SAM and ARM-containing protein), along with other molecules such as TIRP, TRIF, TIRAP, and MyD88, is thought to serve as an adaptor protein for the TLRs that allows for the activation of downstream kinases and NF-κB, and ultimately the expression of proteins involved in host defense. While SARM has not been conclusively shown to associate directly with TLRs, the presence of a Toll-interleukin-1 (TIR) domain in SARM is consistent with a role as a signaling molecule.

Synonyms

SARM, SAMD2, MyD88-5, KIAA0524, SARM, Sterile alpha and TIR motif-containing protein 1, Sterile alpha and Armadillo repeat protein

Gene Name

SARM1

UniProt

Q6SZW1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. SARM antibody recognize the longest isoform.

Immunogen

SARM antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human SARM. The immunogen is located within amino acids 30 - 80 of SARM.

Clonality

Polyclonal

Tissue Specificity

Predominantly expressed in brain, kidney and liver. Expressed at lower level in placenta.

Applications

ELISA, WB, IF

Field of Research

Innate Immunity

Purification

SARM Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Negative regulator of MYD88- and TRIF-dependent toll- like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88- dependent activation of JUN/AP-1, TRIF-dependent activation of NF- kappa-B and IRF3, and the phosphorylation of MAPK14/p38.

Molecular Weight

79388 MW

Shipping Conditions

Available

Storage Conditions

SARM antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.