Anti-LEMD2 Antibody

Boster Bio Anti-LEMD2 Antibody (Catalog # A09079) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

The LEM (lamina-associated polypeptide-emerin-MAN1) domain is a motif shared by a group of lamin-interacting proteins of the inner nuclear membrane (INM) and nucleoplasm. One such protein, LEMD2 (LEM domain-containing protein 2), is a lamina-associated protein in the INM involved in nuclear structure organization, containing an N-terminal LEM motif, two transmembrane domains, and a MAN1-Src1p C-terminal (MSC) domain. LEMD2 is a truncated paralog of MAN1, lacking the MAN1-specific C-terminal RNA-recognition motif, but like MAN1 is required for myogenic differentiation. Mutations in LEMD2 are thought be among the possible causes of muscle disease.

Synonyms

NET25, dJ482C21.1, LEM domain-containing protein 2, hLEM2

Gene Name

LEMD2

UniProt

Q8NC56

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

At least two isoforms of LEMD2 are known to exist; this antibody will detect only the longer isoform.

Immunogen

LEMD2 antibody was raised against a 16 amino acid synthetic peptide near the center of human LEMD2. The immunogen is located within amino acids 220 - 270 of LEMD2.

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed.

Applications

ELISA, WB, ICC, IF

Field of Research

Homeostasis

Purification

LEMD2 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Involved in nuclear structure organization (PubMed:16339967) . Required for maintaining the integrity of the nuclear envelope (PubMed:17097643) .

Molecular Weight

56975 MW

Shipping Conditions

Available

Storage Conditions

LEMD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.