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Anti-SDHAF1 Antibody

Boster Bio Anti-SDHAF1 Antibody (Catalog # A11628) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

SDHAF1 (Succinate dehydrogenase complex assembly factor 1) is one of the subunits of the succinate dehydrogenase (SDH) complex (or complex II) of the mitochondrial respiratory chain. SDHAF1 resides in the mitochondria, and is essential for SDH assembly, but does not physically associate with the complex in vivo. Mutations in this gene are associated with SDH-defective infantile leukoencephalopathy (mitochondrial complex II deficiency) . Unlike the related protein SDHAF2, SDHAF1 is not thought to be a tumor suppressor.

Synonyms

LYRM8, LYRM8, Succinate dehydrogenase assembly factor 1, mitochondrial, LYR motif-containing protein 8, SDH assembly factor 1

Gene Name

SDHAF1

UniProt

A6NFY7

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

SDHAF1 antibody is predicted to not cross-react with other SDHAF protein family members.

Immunogen

SDHAF1 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human SDHAF1. The immunogen is located within the last 50 amino acids of SDHAF1.

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed.

Applications

ELISA, WB, ICC, IF

Field of Research

Homeostasis

Purification

SDHAF1 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3.

Molecular Weight

12806 MW

Shipping Conditions

Available

Storage Conditions

SDHAF1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A11628

Product MSDS

https://www.bosterbio.com/msds?sku=A11628

Fragment

IgG

Other Gene Names

Succinate dehydrogenase complex assembly factor 1

Subcellular Location

Mitochondrion matrix

Protein Name

Succinate dehydrogenase complex assembly factor 1

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