Anti-TFCP2L1 Antibody

The Transcription factor CP2-like protein 1 (TFCP2L1) is related to the ubiquitously expressed CP2 family of transcription factors that are generally transcription factors. TFCP2L1 is expressed in a developmentally regulated fashion during embryogenesis and in the epithelial lining of distal convoluted tubules in embryonic and adult kidneys. Recent studies have shown that TFCP2L1 is part of an Oct4-centered protein interaction network in embryonic stem cells. It is thought to modulate the activity of other CP2 family members in a cell specific manner, and is itself regulated by sumoylation at a single major site.

TFCP2L1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human TFCP2L1. The immunogen is located within the first 50 amino acids of TFCP2L1.

Highly expressed in placental JEG-3 cells and very low levels of expression in non-steroidogenic cells. No expression was seen in adrenal NCI-H295A cells or in adrenal tissue.

Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs) (PubMed:25215486, PubMed:26906118) . With KLF2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/STAT3 and Wnt/beta-catenin signaling (By similarity) . Required for normal duct development in the salivary gland and kidney (By similarity) . Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively (By similarity) . Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, OXGR1, CA12, SLC4A1, AQP6 and IC-specific transcription factor FOXI1 (By similarity) . Regulates also the expression of JAG1 and subsequent notch signaling in the collecting duct (By similarity) . JAG1 initiates notch signaling in PCs but inhibits notch signaling in ICs (By similarity) . Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation (By similarity) . Modulates the placental expression of CYP11A1 (PubMed:10644752) .

TFCP2L1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.