Anti-Nicalin NCLN Antibody
Boster Bio Anti-Nicalin NCLN Antibody (Catalog # A12284-1) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
Nicalin, along with its binding partner Nomo, is a novel signaling antagonist to Nodals, signaling factors of the TGF-β superfamily that play a key role in vertebrate development. Nicalin is distantly related to Nicastrin, a component of the Alzheimer's disease-associated gamma-secretase, and is thought to have a similar function. Another protein, TMEM147, has also been recently identified as associating with Nicalin and NOMO as part of the gamma-secretase-like complex.
Synonyms
NET59, Nicalin, Nicastrin-like protein
Gene Name
NCLN
UniProt
Q969V3
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
NCLN antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human NCLN. The immunogen is located within amino acids 390 - 440 of NCLN.
Clonality
Polyclonal
Tissue Specificity
Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart.
Applications
ELISA, WB, IHC-P, IF
Field of Research
Neuroscience
Purification
NCLN Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. .
Molecular Weight
62974 MW
Shipping Conditions
Available
Storage Conditions
NCLN antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Other Gene Names
Nicalin
Subcellular Location
Endoplasmic reticulum membrane
Protein Name
Nicalin
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