Anti-Transmembrane protein 106B TMEM106B Antibody

Boster Bio Anti-Transmembrane protein 106B TMEM106B Antibody (Catalog # A03541) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.

Product Specifications

Background

Transmembrane protein 106B (TMEM106B) is a single-pass transmembrane protein that is thought to be a novel risk factor for frontotemporal lobar degeneration (FTLD), a group of clinically, pathologically and genetically heterogeneous disorders associated with atrophy in the frontal lobe and temporal lobe of the brain. The actual role of TMEM106B, and that of the closely related protein TMEM106A are still undetermined.

Synonyms

Transmembrane protein 106B

Gene Name

TMEM106B

UniProt

Q9NUM4

Host

Rabbit

Reactivity

Human

Cross Reactivity

This TMEM106B antibody is predicted to have no cross-reactivity to TMEM106A.

Immunogen

TMEM106B antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human TMEM106B. The immunogen is located within the first 50 amino acids of TMEM106B.

Clonality

Polyclonal

Tissue Specificity

Expressed in frontal cortex.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Neuroscience

Purification

TMEM106B Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching.

Molecular Weight

31127 MW

Shipping Conditions

Available

Storage Conditions

TMEM106B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.