Anti-Transmembrane protein 106B TMEM106B Antibody
Boster Bio Anti-Transmembrane protein 106B TMEM106B Antibody (Catalog # A03541) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Product Specifications
Background
Transmembrane protein 106B (TMEM106B) is a single-pass transmembrane protein that is thought to be a novel risk factor for frontotemporal lobar degeneration (FTLD), a group of clinically, pathologically and genetically heterogeneous disorders associated with atrophy in the frontal lobe and temporal lobe of the brain. The actual role of TMEM106B, and that of the closely related protein TMEM106A are still undetermined.
Synonyms
Transmembrane protein 106B
Gene Name
TMEM106B
UniProt
Q9NUM4
Host
Rabbit
Reactivity
Human
Cross Reactivity
This TMEM106B antibody is predicted to have no cross-reactivity to TMEM106A.
Immunogen
TMEM106B antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human TMEM106B. The immunogen is located within the first 50 amino acids of TMEM106B.
Clonality
Polyclonal
Tissue Specificity
Expressed in frontal cortex.
Applications
ELISA, WB, IHC-P, IF
Field of Research
Neuroscience
Purification
TMEM106B Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching.
Molecular Weight
31127 MW
Shipping Conditions
Available
Storage Conditions
TMEM106B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Other Gene Names
Transmembrane protein 106B
Subcellular Location
Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Membrane ; Lipid-anchor .
Prediction Reactivity
Mouse, Bovine, Rat
Protein Name
Transmembrane protein 106B
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