Anti-Homeobox protein Nkx-2.2 NKX2-2 Antibody

NKX2-2 (NK2 homeobox 2) is a member of a family of transcription factors that are involved in embryonic development and cell fate. NKX2-2 is crucial in the development of pancreatic islet cell differentiation and activates the ghrelin-promoter in these cells. NKX2-2 is expressed at the onset of pancreatic epithelium formation and becomes restricted to mature α -, β - and PP cells, and in NKX2-2-null mice embryos, all β -cells and most a-cells are replaced by ghrelin-positive cells. NKX2-2 is also thought to be involved in ventral neuronal patterning and floor plate development and commissural axon guidance.

NKX2-2 antibody was raised against a 19 amino acid synthetic peptide near the center of human NKX2-2. The immunogen is located within amino acids 90 - 140 of NKX2-2.

Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity) . May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity) .

NKX2-2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.