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Anti-SPINK2 Antibody

Boster Bio Anti-SPINK2 Antibody (Catalog # A11403) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

Human serine proteinase inhibitor Kazal-type 2 (SPINK2) is required for maintaining normal spermatogenesis and potentially regulates serine protease-mediated apoptosis in male germ cells. It contains a typical kazal domain composed by six cysteine residues forming three disulfide bridges. SPINK2 functions as a trypsin/acrosin inhibitor and is synthesized mainly in the testis and seminal vesicle where its activity is engaged in fertility. SPINK2 plays a role in the pathogenesis of hereditary and chronic pancreatitis.

Synonyms

HUSI-II, Serine protease inhibitor Kazal-type 2, Acrosin-trypsin inhibitor

Gene Name

SPINK2

UniProt

Q8BMY7

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

SPINK2 antibody is predicted to not cross-react with other SPINK family members.

Immunogen

SPINK2 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of mouse SPINK2. The immunogen is located within the last 50 amino acids of SPINK2.

Clonality

Polyclonal

Tissue Specificity

Expressed in sperm (at protein level) . Expressed in testis but not in ovary, brain, heart, kidney or lung. Within testis, expressed in epididymis and germ cells.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Stem Cells

Purification

SPINK2 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Inhibits trypsin in a dose-dependent manner. Required for maintenance of normal spermatogenesis. May be involved in regulating serine protease-dependent germ cell apoptosis.

Molecular Weight

9722 MW

Shipping Conditions

Available

Storage Conditions

SPINK2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A11403

Product MSDS

https://www.bosterbio.com/msds?sku=A11403

Fragment

IgG

Other Gene Names

Serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)

Subcellular Location

Secreted .

Prediction Reactivity

Rat

Protein Name

Serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)

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