Anti-EPAC2 RAPGEF4 Antibody

Boster Bio Anti-EPAC2 RAPGEF4 Antibody (Catalog # A04794) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

EPAC2, also known as Rap guanine nuclear exchange factor 4 and cAMPGEF-II, is belongs to a family of cyclic adenosine monophosphate (cAMP) binding proteins with guanine nucleotide exchange factor. Like the related protein EPAC1, EPAC2 signaling plays a role in numerous cellular processes such as integrin-mediated cell adhesion, muscle contraction, learning and memory, cell proliferation, and inflammation. Recent evidence suggests that EPAC2 induces synapse remodeling and depression, with mutations in its gene being found in patients with autism.

Synonyms

2, EPAC, CGEF2, EPAC2, EPAC 2, Nbla00496, CAMP-GEFII, Rap guanine nucleotide exchange factor 4, Exchange factor directly activated by cAMP 2

Gene Name

RAPGEF4

UniProt

Q8WZA2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

At least two isoforms of EPAC2 are known to exist; this antibody will detect only the larger isoform. EPAC2 antibody is predicted to not cross-react with EPAC2

Immunogen

EPAC2 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human EPAC2. The immunogen is located within the first 50 amino acids of EPAC2.

Clonality

Polyclonal

Tissue Specificity

Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Signal Transduction

Purification

EPAC2 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2 (By similarity) .

Molecular Weight

115522 MW

Shipping Conditions

Available

Storage Conditions

EPAC2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.