Anti-ANKLE2 Antibody
Boster Bio Anti-ANKLE2 Antibody (Catalog # A11367) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. ANKLE2 (Ankyrin repeat and LEM domain containing 2) is a member of ankyrin repeat and LEM domain containing family. It is a potential single-pass membrane protein that contains three ankyrin repeats and a Lem domain. Ankyrin repeats mediate protein-protein interactions and are among the most common structural motifs in known proteins. The function of this protein is still under investigation.
Synonyms
Lem4, LEMD7, KIAA0692, LEM4, Ankyrin repeat and LEM domain-containing protein 2, LEM domain-containing protein 4
Gene Name
ANKLE2
UniProt
Q86XL3
Host
Chicken
Reactivity
Human, Mouse, Rat
Cross Reactivity
Three isoforms of ANKLE2 are known to exist; this antibody will detect all three. ANKLE2 antibody is predicted to not cross-react with ANKLE1.
Immunogen
ANKLE2 antibody was raised against a 19 amino acid synthetic peptide near the center of human ANKLE2. The immunogen is located within amino acids 280 - 330 of ANKLE2.
Clonality
Polyclonal
Applications
ELISA, WB
Field of Research
Cancer, Cell Cycle
Purification
ANKLE2 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development (PubMed:25259927) .
Molecular Weight
104114 MW
Shipping Conditions
Available
Storage Conditions
ANKLE2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgY
Other Gene Names
Ankyrin repeat and LEM domain containing 2
Subcellular Location
Endoplasmic reticulum membrane
Protein Name
Ankyrin repeat and LEM domain containing 2
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
VAng-Wyb1142-50gEcoli 50 µg (E. coli)
Recombinant Salmonella mucB Protein (aa 1-421)
Sign In for Pricing
View Details 
bs-11871R-Cy3 100 µL
LIM kinase 1 + 2 Polyclonal Antibody, Cy3 Conjugated
Sign In for Pricing
View Details 
46389114 3x 1.0 µg
Tcfcp2 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)
Sign In for Pricing
View Details