Anti-ANKLE1 Antibody

Boster Bio Anti-ANKLE1 Antibody (Catalog # A14094) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. ANKLE1 (Ankyrin repeat and LEM domain containing 1) is a member of ankyrin repeat and LEM domain containing family. It is a potential single-pass membrane protein that contains ankyrin repeats and a Lem domain. Ankyrin repeats mediate protein-protein interactions and are among the most common structural motifs in known proteins. While the function of this protein is still under investigation, its gene locus has been associated with susceptibility to ovarian and breast cancer.

Synonyms

LEM3, LEMD6, ANKRD41, LEM3, Ankyrin repeat and LEM domain-containing protein 1, Ankyrin repeat domain-containing protein 41

Gene Name

ANKLE1

UniProt

Q8NAG6

Host

Chicken

Reactivity

Human, Mouse, Rat

Cross Reactivity

Two isoforms of ANKLE1 are known to exist. ANKLE1 antibody is predicted to not cross-react with ANKLE2

Immunogen

ANKLE1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human ANKLE1. The immunogen is located within the last 50 amino acids of ANKLE1.

Clonality

Polyclonal

Tissue Specificity

Expression is predominant in adult bone marrow.

Applications

ELISA, WB

Field of Research

Cancer, Cell Cycle

Purification

ANKLE1 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Endonuclease that probably plays a role in the DNA damage response and DNA repair.

Molecular Weight

66890 MW

Shipping Conditions

Available

Storage Conditions

ANKLE1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.