Anti-Thymopoietin TMPO Antibody

Thymopoietin (TMPO), also known as LAP2, is a widely expressed lem-domain-containing nuclear protein that is thought to play an important role in the regulation of nuclear architecture by binding lamin B1 and chromosomes in a manner regulated by phosphorylation during mitosis. Thymopoietin associates with nucleoplasmic lamins A/C, which are encoded by the dilated cardiomyopathy (DCM) gene LMNA; mutations in Thymopoietin disrupt this binding, suggesting that Thymopoietin may be a candidate disease gene for DCM.

At least three isoforms of Thymopoietin are known to exist; this antibody will detect all isoforms. Thymopoietin antibody is predicted to not cross-react with other LEM domain-containing proteins.

Thymopoietin antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human Thymopoietin. The immunogen is located within amino acids 80 - 130 of Thymopoietin.

May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.

Thymopoietin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.