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Anti-ECRG2 SPINK7 Antibody

Boster Bio Anti-ECRG2 SPINK7 Antibody (Catalog # A11563) . Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

The esophageal cancer-susceptibility gene 2 (ECRG2), also known as SPINK7, is a novel tumor suppressor gene identified from the human esophagus. It interacts directly with metallothionein 2A and urokinase-type plasminogen activator (uPA), and downregulates the activity of uPA, leading to reduced cancer cell migration, invasion and metastasis. ECRG2 forms a complex with uPA and its receptor uPAR, modifying the dynamic association of uPAR with beta1 integrins and disrupting the Src/MAP kinase pathway that normally stimulates cell migration and invasion. ECRG2 may thus represent a novel therapeutic target for cancer.

Synonyms

ECG2, ECRG2, ECG2, UNQ745/PRO1474, Serine protease inhibitor Kazal-type 7, Esophagus cancer-related gene 2 protein, ECRG-2

Gene Name

SPINK7

UniProt

P58062

Host

Chicken

Reactivity

Human, Mouse, Rat

Cross Reactivity

ECRG2 antibody is predicted to not cross-react with other ECRG family members

Immunogen

ECRG2 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human ECRG2. The immunogen is located within the last 50 amino acids of ECRG2.

Clonality

Polyclonal

Applications

ELISA, WB, IHC-P

Field of Research

Cancer, Cell Cycle

Purification

ECRG2 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Probable serine protease inhibitor.

Molecular Weight

9232 MW

Shipping Conditions

Available

Storage Conditions

ECRG2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgY

Other Gene Names

Serine peptidase inhibitor, Kazal type 7

Subcellular Location

Secreted .

Protein Name

Serine peptidase inhibitor, Kazal type 7

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