Anti-ECRG1 TMPRSS11A Antibody

Boster Bio Anti-ECRG1 TMPRSS11A Antibody (Catalog # A09776) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Epidermal type-II transmembrane serine protease (ECRG1), also known as TMPRSS11A, is a member of a novel esophageal cancer-related gene family. It is a type-II transmembrane serine protease which may play a role in cellular senescence. It is expressed in esophagus, liver, colon and lung. Overexpression of ECRG1 inhibits cell growth and induces G1 cell cycle arrest. It is down-regulated in esophagus cancers (EC) and might play important roles in the initiation and progression of EC.

Synonyms

ECRG1, ECRG1, HATL1, HESP, Transmembrane protease serine 11A, Airway trypsin-like protease 1

Gene Name

TMPRSS11A

UniProt

Q6ZMR5

Host

Chicken

Reactivity

Human, Mouse, Rat

Cross Reactivity

At least two isoforms of ECRG1 are known to exist; ECRG1 antibody is predicted to not cross-react with other ECRG family members.

Immunogen

ECRG1 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human ECRG1. The immunogen is located within amino acids 300 - 350 of ECRG1.

Clonality

Polyclonal

Tissue Specificity

Expressed in esophagus, liver, colon and lung. Down-regulated in esophagus cancers.

Applications

ELISA, WB

Field of Research

Cancer, Cell Cycle

Purification

ECRG1 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.

Molecular Weight

47569 MW

Shipping Conditions

Available

Storage Conditions

ECRG1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.